Plagues can alter the course of civilizations, and they have. The Athenians lost a war in 430 BC. Large number of Roman soldiers were killed, including the emperor around 180 AD. A number of others impacted Europe and Africa. Then came the Asian and American ones. A lot had to do with hygiene and cultural practices that allowed plagues or viruses to infect large populations. Man-made? Or, greed? This can also play into man-made conflicts for the purpose of gaining economic power. Ezekiel 27:27 Your riches, wares, and merchandise, Your mariners and pilots, Your caulkers and merchandisers, All your men of war who are in you, And the entire company which is in your midst, Will fall into the midst of the seas on the day of your ruin. Tyre was a very successful port and with that came success in trading and shipping. It was a very successful business ecosystem and port city that made Tyre a "global economic hub". But they were too re...